How I Treat How I treat Burkitt lymphoma in adults
نویسندگان
چکیده
BG is a 40-year-oldmanwith pastmedical history significant for type 2 diabetes, obesity, and hypertension who presented with hemoptysis. After receiving antibiotics for presumed sinusitis, he was started on prednisone with worsening bleeding. Subsequent laryngoscopic evaluation revealed a nasopharyngeal mass (4.8 3 2.2 cm on magnetic resonance imaging). On biopsy, the histologic appearance and immunophenotype (CD20 and CD10 positive, bcl-2 negative) were consistent with Burkitt lymphoma (BL). Fluorescence in situ hybridization confirmed t(8;14). Positron emission tomography (PET)/computed tomography (CT) revealed additional sites of disease in the liver and bone. Bone marrow biopsy showed 25% involvement. He had no fevers but complained of nondrenching sweats and 10-pound weight loss. Laboratory studies were notable for normal creatinine and complete blood count. Uric acid and lactate dehydrogenase (LDH) were elevated at 9.1 mg/dL and 538 U/L, respectively.
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